Activation of AMPK downstream of NMDARs

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R-HSA-9619483
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Pathway
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Homo sapiens
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Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease (Mairet-Coello et al. 2013).

Literature References
PubMed ID Title Journal Year
23583109 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Courchet, V, Polleux, F, Pieraut, S, Courchet, J, Mairet-Coello, G, Maximov, A

Neuron 2013
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