Activation of AMPK downstream of NMDARs

Stable Identifier
R-HSA-9619483
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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Activation of AMPK downstream of NMDARs
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Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease (Mairet-Coello et al. 2013).

Literature References
PubMed ID Title Journal Year
23583109 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Mairet-Coello, G, Courchet, J, Pieraut, S, Courchet, V, Maximov, A, Polleux, F

Neuron 2013
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BioModels Database
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-17)