Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease (Mairet-Coello et al. 2013).
Mairet-Coello, G, Courchet, J, Pieraut, S, Courchet, V, Maximov, A, Polleux, F
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