Reactome | CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

Schema > Reaction > Entries

CES1 trimer hydrolyses ACEI pro-drugs to ACEIs Show undefined attributes

authored	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
catalystActivity	[CatalystActivity:9619047] carboxylesterase activity of CES1 trimer [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
crossReference	[DatabaseIdentifier:9916370] RHEA:21164
dbId	9619024
displayName	CES1 trimer hydrolyses ACEI pro-drugs to ACEIs
edited	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
eventOf	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9619034] ACEIs translocate from ER lumen to extracellular region - Homo sapiens
input	[DefinedSet:R-ALL-9619052] ACEI pro-drugs [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5693696] Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine [LiteratureReference:5693675] Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin [LiteratureReference:9619020] In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	CES1 trimer hydrolyses ACEI pro-drugs to ACEIs
orthologousEvent	[Reaction:R-DDI-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Dictyostelium discoideum [Reaction:R-CEL-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Caenorhabditis elegans [Reaction:R-DME-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Drosophila melanogaster [Reaction:R-GGA-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Gallus gallus [Reaction:R-XTR-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Xenopus tropicalis [Reaction:R-DRE-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Danio rerio [Reaction:R-SSC-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Sus scrofa [Reaction:R-BTA-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Bos taurus [Reaction:R-CFA-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Canis familiaris [Reaction:R-RNO-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Rattus norvegicus [Reaction:R-MMU-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Mus musculus
output	[SimpleEntity:R-ALL-140972] Alcohol [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [DefinedSet:R-ALL-9619021] hydrolysed ACEIs [endoplasmic reticulum lumen]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2018-12-09
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:9619120] Toomey, John, 2018-09-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9619024
summation	[Summation:9619038] Mammalian carboxylesterases (CES) are a well conserved famil...
updateTrackers	[UpdateTracker:9919421] Update Tracker - [Reaction:9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - v90:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9919421] Update Tracker - [Reaction:9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - v90:[add_removeOutput]
(precedingEvent)	[BlackBoxEvent:R-HSA-9619034] ACEIs translocate from ER lumen to extracellular region
(hasEvent)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins

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