Reactome | ACEIs translocate from ER lumen to extracellular region

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
category	uncertain
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:984] extracellular region
created	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
dbId	9619034
displayName	ACEIs translocate from ER lumen to extracellular region
edited	[InstanceEdit:9619045] Jassal, Bijay, 2018-09-14
eventOf	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent	[Reaction:R-HSA-9614933] ACEIs bind ACE - Homo sapiens
input	[DefinedSet:R-ALL-9619021] hydrolysed ACEIs [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9614927] Evaluation of angiotensin converting enzyme (ACE) in the pharmacokinetics and pharmacodynamics of ACE inhibitors
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ACEIs translocate from ER lumen to extracellular region
output	[DefinedSet:R-ALL-9619018] hydrolysed ACEIs [extracellular region]
precedingEvent	[Reaction:R-HSA-9619024] CES1trimer hydrolyses ACEI pro-drugs to ACEIs - Homo sapiens
releaseDate	2018-12-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9619120] Toomey, John, 2018-09-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9619034
summation	[Summation:9619117] To exert their biological effects on extracellular angiotens...

(hasEvent)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)	[Reaction:R-HSA-9614933] ACEIs bind ACE

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