Reactome | CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

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CES1 trimer hydrolyses ACEI pro-drugs to ACEIs Show undefined attributes

catalystActivity	[CatalystActivity:11043771] carboxylesterase activity of CES1 trimer [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11043773
displayName	CES1 trimer hydrolyses ACEI pro-drugs to ACEIs
eventOf	[Pathway:R-DDI-2022377] Metabolism of Angiotensinogen to Angiotensins - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Homo sapiens
input	[DefinedSet:R-ALL-9619052] ACEI pro-drugs [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CES1 trimer hydrolyses ACEI pro-drugs to ACEIs
output	[SimpleEntity:R-ALL-140972] Alcohol [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [DefinedSet:R-ALL-9619021] hydrolysed ACEIs [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9619024
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-2022377] Metabolism of Angiotensinogen to Angiotensins
(inferredTo)	[Reaction:R-HSA-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

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