Reactome | CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

Stable Identifier

R-HSA-9619024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

4/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CES1 trimer hydrolyses ACEI pro-drugs to ACEIs

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mammalian carboxylesterases (CES) are a well conserved family that catalyse the hydrolysis of a vast array of endogenous and exogenous substrates including environmental toxins and drugs. CES-mediated hydrolysis plays an important role in the disposition of a number of widely prescribed therapeutic agents from a diverse range of drug classes including angiotensin-converting enzyme inhibitors (ACEIs). In humans, two carboxylesterases, CES1 and CES2, are important enzymes in drug metabolism (Brzezinski et al. 1994, Pindel et al. 1997). Both are expressed in liver but levels of CE1 are much higher than CE2. Most ACEI prodrugs (except captopril and lisinopril) are administered as esterified prodrugs which are probably susceptible to hydrolysis by CES1 trimer (Thomsen et al. 2014). The resultant active drugs (suffix 'prilat') can inhibit the conversion of angiotensin I to angiotensin II, thereby contributing to the antihypertensive effect of these drugs. Some CES1 genetic variants (eg. G143E) may impair ACEI activation, and consequently affect therapeutic outcomes of ACEI prodrugs (Wang et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
24141856	In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors Linnet, K, Rasmussen, HB, Thomsen, R	Drug Metab. Dispos.	2014
9169443	Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin Bosron, WF, Dean, RA, Kedishvili, NY, Pindel, EV, Zhang, J, Brzezinski, MR, Abraham, TL	J. Biol. Chem.	1997
7980644	Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine Bosron, WF, Dean, RA, Stone, CL, Brzezinski, MR, Abraham, TL	Biochem. Pharmacol.	1994