SOX10 dimer binds the POU3F1 promoter

Stable Identifier
R-HSA-9613648
Type
Reaction [binding]
Species
Homo sapiens
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SOX10 binds as a dimer to the Schwann cell enhancer (SCE) element in the promoter of the POU3F1 gene (Jagalur et al, 2011; Schreiner et al, 2007; Ghazvini et al, 2002; Mandemakers et al, 2000). SOX10 mediates recruitment of chromatin remodeling complexes and histone deacetlyases, including HDAC2 and SMARCA4, promoting transcriptional activation of POU3F1 (Jacob et al, 2011; Weider et al, 2012).
POU3F1 protein (also known as OCT6) is required in conjunction with EGR2 to ensheath axonal neurons of the peripheral nervous system with myelin (reviewed in Svaren and Meijer, 2008). The myelination program is initiated by extracellular axonal signals such as NRG, Neuregulin1, Notch ligands and neurotrophins and is transmitted to the nucleus, ultimately controling expression of myelin-related genes, including myelin protein zero (MPZ) and myelin basic protein (MBP), among others. After synthesis, OCT6 acts in conjunction with SOX10 and EGR2, a master regulator of myelination, to drive expression of these genes (reviewed in Svaren and Meijer, 2008; Stolt and Wegner, 2016).

Literature References
PubMed ID Title Journal Year
22814607 Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination

Weider, M, Küspert, M, Bischof, M, Vogl, MR, Hornig, J, Loy, K, Kosian, T, Müller, J, Hillgärtner, S, Tamm, ER, Metzger, D, Wegner, M

Dev. Cell 2012
21423190 HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Jacob, C, Christen, CN, Pereira, JA, Somandin, C, Baggiolini, A, Lötscher, P, Ozçelik, M, Tricaud, N, Meijer, D, Yamaguchi, T, Matthias, P, Suter, U

Nat. Neurosci. 2011
18803322 The molecular machinery of myelin gene transcription in Schwann cells

Svaren, J, Meijer, D

Glia 2008
21653862 Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding

Jagalur, NB, Ghazvini, M, Mandemakers, W, Driegen, S, Maas, A, Jones, EA, Jaegle, M, Grosveld, F, Svaren, J, Meijer, D

J. Neurosci. 2011
10856243 A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration

Mandemakers, W, Zwart, R, Jaegle, M, Walbeehm, E, Visser, P, Grosveld, F, Meijer, D

EMBO J. 2000
26423937 Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination

Stolt, CC, Wegner, M

Brain Res. 2016
12198163 A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration

Ghazvini, M, Mandemakers, W, Jaegle, M, Piirsoo, M, Driegen, S, Koutsourakis, M, Smit, X, Grosveld, F, Meijer, D

EMBO J. 2002
17699610 Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages

Schreiner, S, Cossais, F, Fischer, K, Scholz, S, Bösl, MR, Holtmann, B, Sendtner, M, Wegner, M

Development 2007
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