EGR1 gene expression

Stable Identifier
R-HSA-9612516
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EGR1 gene expression
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Early Growth Response 1 (EGR) is an immediate early gene that is rapidly expressed downstream of a number of stimuli. It encodes a Cys2-His2 zinc finger transcription factor that regulates expression of genes involved in stress response, differentiation and neuronal development (reviewed in Pagel and Deindl, 2001; Bahrami and Drabløs, 2016; Perez-Cadahia et al, 2011; Herdegen and Leah, 1998; O'Donovan et al, 1999).
Expression of EGR1 depends on binding of phosphorylated TCF protein ELK1 and its transcriptional coactivator SRF (serum response factor) to their cognate DNA binding sequences in the promoters (Hooker et al, 2017; De Franco et al, 1993; Harada et al, 2001; reviewed in Herdegen and Leah, 1998). In addition to SRF and TCF binding sites, the EGR1 promoter also contain consensus binding sequences for AP-1 and CREB, as well as binding sites for EGR1 protein itself (Schwachtgen et al, 2000; Thiel et al, 2000; Svaren et al, 1996; David et al, 2005; Tyan et al, 2008; reviewed in Page; and Deindl, 2001). Expression of EGR1 is limited by a negative feedback loop mediated by the binding of a complex of EGR1 protein with a repressor protein of the NAB family (NGF1A binding protein) to the EGR1 binding site (Cao et al, 1990; Thiel et al, 2000; Svaren et al, 1996).
Literature References
PubMed ID Title Journal Year
11018254 The human transcriptional repressor protein NAB1: expression and biological activity

Thiel, G, Kaufmann, K, Magin, A, Lietz, M, Bach, K, Cramer, M

Biochim. Biophys. Acta 2000
8668170 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1996
22053691 Early growth response 1--a transcription factor in the crossfire of signal transduction cascades

Pagel, JI, Deindl, E

Indian J. Biochem. Biophys. 2011
11331872 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T, Morooka, T, Ogawa, S, Nishida, E

Nat. Cell Biol. 2001
8483478 Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate

DeFranco, C, Damon, DH, Endoh, M, Wagner, JA

Mol. Endocrinol. 1993
10203854 The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

O'Donovan, KJ, Tourtellotte, WG, Millbrandt, J, Baraban, JM

Trends Neurosci. 1999
9858769 Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins

Herdegen, T, Leah, JD

Brain Res. Brain Res. Rev. 1998
28275114 Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4

Hooker, E, Baldwin, C, Roodman, V, Batra, A, Isa, NN, Takano, T, Lemay, S

Biochem. J. 2017
15733869 Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB

David, S, Kalb, RG

FEBS Lett. 2005
10826704 Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element

Schwachtgen, JL, Campbell, CJ, Braddock, M

DNA Seq. 2000
21326363 Activation and function of immediate-early genes in the nervous system

Pérez-Cadahía, B, Drobic, B, Davie, JR

Biochem. Cell Biol. 2011
18088355 Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation

Tyan, SW, Tsai, MC, Lin, CL, Ma, YL, Lee, EH

J. Neurochem. 2008
27220739 Gene regulation in the immediate-early response process

Bahrami, S, Drabløs, F

Adv Biol Regul 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm] (Homo sapiens)
Active Unit
NAB1 [nucleoplasm]
NAB2 [nucleoplasm]
Positively by
Regulator
EGR1 gene:EGR1 [nucleoplasm] (Homo sapiens)
Active Unit
EGR1 gene [nucleoplasm]
Regulator
EGR1 gene:p-S133 CREB:p-S103 SRF [nucleoplasm] (Homo sapiens)
Active Unit
p-S103 SRF [nucleoplasm]
p-S133-CREB1 homodimer [nucleoplasm]
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-06-28)
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