Reactome | EGR1 gene expression

EGR1 gene expression

Stable Identifier

R-HSA-9612516

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        EGR1 gene expression (Homo sapiens)

General

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Early Growth Response 1 (EGR) is an immediate early gene that is rapidly expressed downstream of a number of stimuli. It encodes a Cys2-His2 zinc finger transcription factor that regulates expression of genes involved in stress response, differentiation and neuronal development (reviewed in Pagel and Deindl, 2001; Bahrami and Drabløs, 2016; Perez-Cadahia et al, 2011; Herdegen and Leah, 1998; O'Donovan et al, 1999).
Expression of EGR1 depends on binding of phosphorylated TCF protein ELK1 and its transcriptional coactivator SRF (serum response factor) to their cognate DNA binding sequences in the promoters (Hooker et al, 2017; De Franco et al, 1993; Harada et al, 2001; reviewed in Herdegen and Leah, 1998). In addition to SRF and TCF binding sites, the EGR1 promoter also contain consensus binding sequences for AP-1 and CREB, as well as binding sites for EGR1 protein itself (Schwachtgen et al, 2000; Thiel et al, 2000; Svaren et al, 1996; David et al, 2005; Tyan et al, 2008; reviewed in Page; and Deindl, 2001). Expression of EGR1 is limited by a negative feedback loop mediated by the binding of a complex of EGR1 protein with a repressor protein of the NAB family (NGF1A binding protein) to the EGR1 binding site (Cao et al, 1990; Thiel et al, 2000; Svaren et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8668170	NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J	Mol. Cell. Biol.	1996
11018254	The human transcriptional repressor protein NAB1: expression and biological activity Thiel, G, Kaufmann, K, Magin, A, Lietz, M, Bach, K, Cramer, M	Biochim. Biophys. Acta	2000
22053691	Early growth response 1--a transcription factor in the crossfire of signal transduction cascades Pagel, JI, Deindl, E	Indian J. Biochem. Biophys.	2011
11331872	ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Harada, T, Morooka, T, Ogawa, S, Nishida, E	Nat. Cell Biol.	2001
8483478	Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate DeFranco, C, Damon, DH, Endoh, M, Wagner, JA	Mol. Endocrinol.	1993
10203854	The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience O'Donovan, KJ, Tourtellotte, WG, Millbrandt, J, Baraban, JM	Trends Neurosci.	1999
9858769	Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins Herdegen, T, Leah, JD	Brain Res. Brain Res. Rev.	1998
28275114	Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4 Hooker, E, Baldwin, C, Roodman, V, Batra, A, Isa, NN, Takano, T, Lemay, S	Biochem. J.	2017
15733869	Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB David, S, Kalb, RG	FEBS Lett.	2005
10826704	Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element Schwachtgen, JL, Campbell, CJ, Braddock, M	DNA Seq.	2000
21326363	Activation and function of immediate-early genes in the nervous system Pérez-Cadahía, B, Drobic, B, Davie, JR	Biochem. Cell Biol.	2011
18088355	Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation Tyan, SW, Tsai, MC, Lin, CL, Ma, YL, Lee, EH	J. Neurochem.	2008
27220739	Gene regulation in the immediate-early response process Bahrami, S, Drabløs, F	Adv Biol Regul	2016