SOS1-mediated nucleotide exchange of RAS downstream of FLT3

Stable Identifier
R-HSA-9607304
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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SOS1-mediated nucleotide exchange of RAS downstream of FLT3
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Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References
PubMed ID Title Journal Year
8493579 Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

Gale, NW, Camonis, JH, Chardin, P, Schlessinger, J, Wigler, MH, Bar-Sagi, D, Van Aelst, L

Science 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of Active FLT3:GRB2:SOS1 [plasma membrane]

Physical Entity
Active FLT3:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)
Authored
Varusai, TM  (2019-01-14)
Reviewed
Traer, E  (2019-05-03)
Joshi, S  (2019-05-21)
Created
Varusai, TM  (2018-05-02)
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