Reactome | SOS1-mediated nucleotide exchange of RAS downstream of FLT3

SOS1-mediated nucleotide exchange of RAS downstream of FLT3

Stable Identifier

R-HSA-9607304

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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SOS1-mediated nucleotide exchange of RAS downstream of FLT3

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Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).

Literature References

PubMed ID	Title	Journal	Year
8493579	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D	Science	1993