Reactome | Activated NTRK3 signals through PI3K

Activated NTRK3 signals through PI3K

Stable Identifier

R-HSA-9603381

Type

Pathway

Species

Homo sapiens

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The PI3K complex, composed of PIK3R1 and PIK3CA, co-immunoprecipitates with NTRK3 (TRKC), activated by NTF3 (NT-3) treatment (Yuen and Mobley 1999). Activation of NTRK3 correlates with activating phosphorylation of AKT, the main mediator of PI3K signaling (Tognon et al. 2001, Jin et al. 2008), and is dependent on PI3K activity (Tognon et al. 2001). NTRK3-mediated activation of PI3K signaling depends on SRC activation and the adaptor protein IRS1, but the exact mechanism is not known (Morrison et al. 2002, Lannon et al. 2004, Jin et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11751416	The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation Tognon, C, Garnett, M, Kenward, E, Kay, R, Morrison, K, Sorensen, PH	Cancer Res.	2001
17991742	c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway Jin, W, Yun, C, Jeong, J, Park, Y, Lee, HD, Kim, SJ	J. Biol. Chem.	2008
12173038	ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation Morrison, KB, Tognon, CE, Garnett, MJ, Deal, C, Sorensen, PH	Oncogene	2002
14668342	A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation Lannon, CL, Martin, MJ, Tognon, CE, Jin, W, Kim, SJ, Sorensen, PH	J. Biol. Chem.	2004
10486198	Early BDNF, NT-3, and NT-4 signaling events Yuen, EC, Mobley, WC	Exp. Neurol.	1999