The listed studies describe an activation of IRAK-TRAF6-TAK1...

created [InstanceEdit:2428861] Shamovsky, V, 2012-08-08
dbId 2428857
displayName The listed studies describe an activation of IRAK-TRAF6-TAK1...
schemaClass Summation
text The listed studies describe an activation of IRAK-TRAF6-TAK1 axes downstream of IL1 receptor signaling cascade, which is mediated by its cytosolic domain called Toll/IL1R (TIR) domain. TLRs and IL1R are thought to share a similar downstream signaling pathway due to a high homology of their C-terminal TIR domains.
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