Reactome | IKBKG subunit of IKK complex binds polyubiquinated RIP1

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IKBKG subunit of IKK complex binds polyubiquinated RIP1 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
dbId	937029
displayName	IKBKG subunit of IKK complex binds polyubiquinated RIP1
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-937041] IKK complex recruitment mediated by RIP1 - Homo sapiens
input	[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol] [Complex:R-HSA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451569] Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] [LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IKBKG subunit of IKK complex binds polyubiquinated RIP1
orthologousEvent	[Reaction:R-GGA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Gallus gallus [Reaction:R-SSC-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Sus scrofa [Reaction:R-BTA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Bos taurus [Reaction:R-CFA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Canis familiaris [Reaction:R-RNO-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Rattus norvegicus [Reaction:R-MMU-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Mus musculus
output	[Complex:R-HSA-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-937029
summation	[Summation:940405] Structural studies showed that NEMO binds both Lys-63- and l...

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(hasEvent)

[Pathway:R-HSA-937041] IKK complex recruitment mediated by RIP1

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