Reactome | IKBKG subunit of IKK complex binds polyubiquinated RIP1

IKBKG subunit of IKK complex binds polyubiquinated RIP1

Stable Identifier

R-HSA-937029

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        IKK complex recruitment mediated by RIP1 (Homo sapiens)
        
        IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)

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IKBKG subunit of IKK complex binds polyubiquinated RIP1

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Structural studies showed that NEMO binds both Lys-63- and linear polyubiquitin chains,both critical for NF-kB activation.

Literature References

PubMed ID	Title	Journal	Year
16603398	Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO Deng, L, Chen, ZJ, Pineda, G, Xia, ZP, Ea, CK	Mol Cell	2006
16547522	Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected] Srinivasula, SM, Conze, DB, Ashwell, JD, Li, T, Wu, CJ	Nat Cell Biol	2006