Processing of caspases

Stable Identifier
R-HSA-933532
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Processing of caspases
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Processing of caspases is required for activation of downstream signaling and dsRNA stimulation inducese the processing of these caspases. The nonapoptotic caspase function of both caspase-8 and -10 does not require the protease activity and the DED-containing prodomains are sufficient for NF-kB activation.
Literature References
PubMed ID Title Journal Year
16585540 Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

Takahashi, K, Kawai, T, Kumar, H, Sato, S, Yonehara, S, Akira, S

J Immunol 2006
18761323 Non-apoptotic functions of caspase-8

Maelfait, J, Beyaert, R

Biochem Pharmacol 2008
11717445 Caspase-10 is an initiator caspase in death receptor signaling

Wang, J, Chun, HJ, Wong, W, Spencer, DM, Lenardo, MJ

Proc Natl Acad Sci U S A 2001
16618810 Caspases leave the beaten track: caspase-mediated activation of NF-kappaB

Lamkanfi, M, Declercq, W, Vanden Berghe, T, Vandenabeele, P

J Cell Biol 2006
12884866 Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

Shikama, Y, Yamada, M, Miyashita, T

Eur J Immunol 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]

Physical Entity
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
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