Reactome | ABCG2 tetramer transports heme from cytosol to extracellular region

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ABCG2 tetramer transports heme from cytosol to extracellular region Show undefined attributes

catalystActivity	[CatalystActivity:10484397] ABC-type heme transporter activity of ABCG2 tetramer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10484399
displayName	ABCG2 tetramer transports heme from cytosol to extracellular region
eventOf	[Pathway:R-SSC-189451] Heme biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9661419] ALB binds extracellular heme - Sus scrofa
inferredFrom	[Reaction:R-HSA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-71185] ferroheme [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ABCG2 tetramer transports heme from cytosol to extracellular region ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate Export of heme to the blood by ABCG2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-917877] heme [extracellular region] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SSC-9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-917979
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-189451] Heme biosynthesis [Pathway:R-SSC-917937] Iron uptake and transport
(precedingEvent)	[Reaction:R-SSC-9661419] ALB binds extracellular heme
(inferredTo)	[Reaction:R-HSA-917979] ABCG2 tetramer transports heme from cytosol to extracellular region

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