Reactome | Fe3+ dissociates from holoTF:TFRC dimer

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Fe3+ dissociates from holoTF:TFRC dimer Show undefined attributes

category	dissociation
compartment	[Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10590175
displayName	Fe3+ dissociates from holoTF:TFRC dimer
eventOf	[Pathway:R-DRE-917977] Transferrin endocytosis and recycling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Danio rerio [Reaction:R-DRE-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane - Danio rerio
inferredFrom	[Reaction:R-HSA-917835] Fe3+ dissociates from holoTF:TFRC dimer - Homo sapiens
input	[Complex:R-DRE-917799] holoTF:TFRC dimer [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Fe3+ dissociates from holoTF:TFRC dimer
output	[Complex:R-DRE-917912] apoTF:TFRC dimer [endosome membrane] 4 × [SimpleEntity:R-ALL-917966] Fe3+ [endosome lumen]
precedingEvent	[Reaction:R-DRE-917841] Acidification of Tf:TfR1 containing endosome - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-917835
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-917977] Transferrin endocytosis and recycling
(precedingEvent)	[Reaction:R-DRE-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ [Reaction:R-DRE-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane
(inferredTo)	[Reaction:R-HSA-917835] Fe3+ dissociates from holoTF:TFRC dimer

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