Reactome | SHC1 mediates cytokine-induced phosphorylation of GAB2

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SHC1 mediates cytokine-induced phosphorylation of GAB2 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:912521] Jupe, S, 2010-07-09
dbId	912527
displayName	SHC1 mediates cytokine-induced phosphorylation of GAB2
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-912526] Interleukin receptor SHC signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-912537] Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:507990] Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a [LiteratureReference:507926] New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SHC1 mediates cytokine-induced phosphorylation of GAB2
orthologousEvent	[BlackBoxEvent:R-GGA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Gallus gallus [BlackBoxEvent:R-SSC-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Sus scrofa [BlackBoxEvent:R-BTA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Bos taurus [BlackBoxEvent:R-CFA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Canis familiaris [BlackBoxEvent:R-RNO-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Rattus norvegicus [BlackBoxEvent:R-MMU-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-912533] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-912527
summation	[Summation:912524] Binding of Gab2 to tyrosine phosphorylated Shc promotes the ...
updateTrackers	[UpdateTracker:9790113] Update Tracker - [BlackBoxEvent:912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - v35:[modifyText, removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9790113] Update Tracker - [BlackBoxEvent:912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - v35:[modifyText, removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-912526] Interleukin receptor SHC signaling
(precedingEvent)	[Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases