Reactome | SHC1 mediates cytokine-induced phosphorylation of GAB2

SHC1 mediates cytokine-induced phosphorylation of GAB2

Stable Identifier

R-HSA-912527

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SHC1 mediates cytokine-induced phosphorylation of GAB2

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Binding of Gab2 to tyrosine phosphorylated Shc promotes the phosphorylation of Gab2 by an unknown kinase. Gab2 becomes tyrosine phosphorylated in response to IL-2 (Brockdorff et al. 2001) and IL-3 (Gu et al. 1998). Chimeric receptors were used to demonstrate that Shc is sufficient for Gab2 tyrosine phosphorylation. In response to IL-3, Grb2 was also required, reflecting that Gab2 is recruited to the activated cytokine receptor complex as a complex of Gab2:Grb2 (Gu et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10982827	New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway Gu, H, Maeda, H, Moon, JJ, Lord, JD, Yoakim, M, Nelson, BH, Neel, BG	Mol Cell Biol	2000
11340297	Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a Brockdorff, JL, Gu, H, Mustelin, T, Kaltoft, K, Geisler, C, Röpke, C, Ødum, N	Exp Clin Immunogenet	2001