Reactome | SHC1 mediates cytokine-induced phosphorylation of GAB2

Schema > BlackBoxEvent > Entries

SHC1 mediates cytokine-induced phosphorylation of GAB2 Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144841
displayName	SHC1 mediates cytokine-induced phosphorylation of GAB2
eventOf	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-RNO-912537] Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SHC1 mediates cytokine-induced phosphorylation of GAB2
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-RNO-912533] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-RNO-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-912527
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling
(precedingEvent)	[Reaction:R-RNO-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases
(inferredTo)	[BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2

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