Reactome | Interleukin receptor SHC signaling

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Interleukin receptor SHC signaling Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:912521] Jupe, S, 2010-07-09
crossReference	[DatabaseIdentifier:12819653] BioModels Database:BIOMD0000001077 [DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313 [DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819481] BioModels Database:BIOMD0000000399 [DatabaseIdentifier:12819483] BioModels Database:BIOMD0000000019 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424
dbId	912526
displayName	Interleukin receptor SHC signaling
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-451927] Interleukin-2 family signaling - Homo sapiens [Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
figure	[Figure:975838] /figures/shc.png
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Homo sapiens [BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Homo sapiens [Reaction:R-HSA-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Homo sapiens [Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-913374] Phosphorylated SHC1 recruits SHIP - Homo sapiens [Reaction:R-HSA-913424] The SHC1:SHIP1 complex is stabilized by GRB2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:453090] The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Interleukin receptor SHC signaling
orthologousEvent	[Pathway:R-GGA-912526] Interleukin receptor SHC signaling - Gallus gallus [Pathway:R-SSC-912526] Interleukin receptor SHC signaling - Sus scrofa [Pathway:R-BTA-912526] Interleukin receptor SHC signaling - Bos taurus [Pathway:R-CFA-912526] Interleukin receptor SHC signaling - Canis familiaris [Pathway:R-RNO-912526] Interleukin receptor SHC signaling - Rattus norvegicus [Pathway:R-MMU-912526] Interleukin receptor SHC signaling - Mus musculus
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-912526
summation	[Summation:913356] Phosphorylation of Shc at three tyrosine residues, 239, 240 ...
updateTrackers	[UpdateTracker:9789197] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v38:[removeHasEvent] [UpdateTracker:9780869] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v62:[removeHasEvent] [UpdateTracker:9790194] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v35:[modifyText, updateContainedRLE] [UpdateTracker:9784610] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v53:[add_removeHasEvent] [UpdateTracker:9783644] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v56:[updateContainedPathway]

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(updatedInstance)

[UpdateTracker:9789197] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v38:[removeHasEvent]
[UpdateTracker:9780869] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v62:[removeHasEvent]
[UpdateTracker:9790194] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v35:[modifyText, updateContainedRLE]
[UpdateTracker:9784610] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v53:[add_removeHasEvent]
[UpdateTracker:9783644] Update Tracker - [Pathway:912526] Interleukin receptor SHC signaling - v56:[updateContainedPathway]

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