Reactome | IFN alpha/beta binds to IFNAR2

Schema > Reaction > Entries

IFN alpha/beta binds to IFNAR2 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10763429
displayName	IFN alpha/beta binds to IFNAR2
eventOf	[Pathway:R-GGA-909733] Interferon alpha/beta signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-909724] Recruitment of IFNAR1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-909720] IFN alpha/beta binds to IFNAR2 - Homo sapiens
input	[DefinedSet:R-GGA-909690] IFN alpha/beta (IFNA/B) [extracellular region] [Complex:R-GGA-918193] IFNAR2:JAK1:STAT2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IFN alpha/beta binds to IFNAR2
output	[Complex:R-GGA-918195] IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane]
regulatedBy	[NegativeRegulation:10763430] Negative regulation by 'IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]' [PositiveRegulation:10763431] Positive regulation by 'IFNAR2:JAK1:STAT2:recombinant IFNB1 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-909720
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-909733] Interferon alpha/beta signaling
(precedingEvent)	[Reaction:R-GGA-909724] Recruitment of IFNAR1
(inferredTo)	[Reaction:R-HSA-909720] IFN alpha/beta binds to IFNAR2