Reactome | ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex

Schema > Reaction > Entries

ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9036302] Rothfels, Karen, 2018-01-31
dbId	9036308
displayName	ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex
edited	[InstanceEdit:9758183] Rothfels, Karen, 2021-11-09
eventOf	[Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9625814] SPHK1 phosphorylates sphingosine in response to E2 stimulation - Homo sapiens [BlackBoxEvent:R-HSA-9624014] SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 - Homo sapiens
input	[Complex:R-HSA-9036303] GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9622925] Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane [LiteratureReference:9622947] Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis [LiteratureReference:9623209] 17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression [LiteratureReference:9623301] 17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression [LiteratureReference:374202] Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells [LiteratureReference:9622951] Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF [LiteratureReference:9623205] Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30 [LiteratureReference:9622966] The G-protein coupled estrogen receptor, GPER: The inside and inside-out story [LiteratureReference:9623201] Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS [LiteratureReference:9622913] A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis [LiteratureReference:9623299] G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production [LiteratureReference:9623296] G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex
output	[Complex:R-HSA-164358] G alpha (s):GTP [plasma membrane] [Complex:R-HSA-167434] G-protein beta-gamma complex [plasma membrane] [Complex:R-HSA-374150] GPER1:ESTG [plasma membrane]
precedingEvent	[Reaction:R-HSA-9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645002] Marino, Maria, 2019-04-24 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9036308
summation	[Summation:9623207] Stimulation of GPER through E2 binding activates nucleotide ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9625814] SPHK1 phosphorylates sphingosine in response to E2 stimulation [BlackBoxEvent:R-HSA-9624014] SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
(hasEvent)	[Pathway:R-HSA-9634597] GPER1 signaling

Cite Us!