Reactome | ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s

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ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:9036306] guanyl-nucleotide exchange factor activity of GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9036302] Rothfels, Karen, 2018-01-31
dbId	9036301
displayName	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
edited	[InstanceEdit:9758183] Rothfels, Karen, 2021-11-09
eventOf	[Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9036308] ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex - Homo sapiens
input	[Complex:R-HSA-9036305] GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9622925] Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane [LiteratureReference:374202] Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells [LiteratureReference:9622920] A transmembrane intracellular estrogen receptor mediates rapid cell signaling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s
orthologousEvent	[Reaction:R-GGA-9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s - Gallus gallus [Reaction:R-CFA-9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s - Canis familiaris [Reaction:R-MMU-9036301] ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-9036303] GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane]
precedingEvent	[Reaction:R-HSA-9036307] GPER:Heterotrimeric G-protein Gs binds ESTG - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645002] Marino, Maria, 2019-04-24 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9036301
summation	[Summation:9623212] Binding of E2 to GPER induces the exchange of GDP for GTP on...

Referrals

(hasEvent)	[Pathway:R-HSA-9634597] GPER1 signaling
(precedingEvent)	[Reaction:R-HSA-9036308] ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex

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