Reactome | SHC1 is phosphorylated downstream of estrogen stimulation of GPER1

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SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:6790063] protein tyrosine kinase activity of unknown kinase [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9624015] Rothfels, Karen, 2018-10-05
dbId	9624014
displayName	SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
edited	[InstanceEdit:9758183] Rothfels, Karen, 2021-11-09
eventOf	[Pathway:R-HSA-9634597] GPER1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9624017] p-SHC1 binds integrin alpha5beta1:fibronectin - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-9623997] SHC1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9622951] Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF [LiteratureReference:9623941] Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30 [LiteratureReference:9623955] G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein [LiteratureReference:9623966] Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway [LiteratureReference:9623969] Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases [LiteratureReference:9623961] Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology [LiteratureReference:9622966] The G-protein coupled estrogen receptor, GPER: The inside and inside-out story [LiteratureReference:9622913] A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis [LiteratureReference:9623951] Estrogen biology: new insights into GPER function and clinical opportunities
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-HSA-9623990] pY-SHC1 [cytosol]
precedingEvent	[Reaction:R-HSA-9036308] ESTG-stimulated dissociation of GPER:heterotrimeric G-protein (s) complex - Homo sapiens
regulatedBy	[PositiveRegulation:9624012] Positive regulation by 'G-protein beta-gamma complex [plasma membrane]' [PositiveRegulation:9624009] Positive regulation by 'MyrG-p-Y419-SRC [plasma membrane]'
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645002] Marino, Maria, 2019-04-24 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9624014
summation	[Summation:9624004] E2 treatment stimulates phosphorylation of MAPK3 and MAPK1 (...

Referrals

(hasEvent)	[Pathway:R-HSA-9634597] GPER1 signaling
(precedingEvent)	[Reaction:R-HSA-9624017] p-SHC1 binds integrin alpha5beta1:fibronectin