Reactome | ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC

ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC

Stable Identifier

R-HSA-9033959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, Golgi membrane

ReviewStatus

5/5

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ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC

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The histo-blood group ABO system transferase (ABO) is the basis of the ABO blood group system. A, B and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of GalNAc), to the B antigen (by addition of Gal) or to the AB antigen (by the addition of both GalNAc and Gal). O group individuals lack such activity. Differences in four critical amino acids (176, 235, 266 and 268) alter the specificity from an A to a B glycosyltransferase (Yamamoto et al. 1990, Yamamoto & McNeill 1996, Seto et al. 1999, Alfaro et al. 2008). The histo-blood group A transferase (ABO-A) utilises UDP-GalNAc to transfer N-acetylgalactosamine (GalNAc) to the H antigen formed via Type 2 chains to form the A antigen (Patenaude et al. 2002, Persson et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
2333095	Molecular genetic basis of the histo-blood group ABO system Marken, J, White, T, Yamamoto, F, Hakomori, S, Clausen, H	Nature	1990
18192272	ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes Seto, NO, Bai, Y, Borisova, SN, Persson, M, Alfaro, JA, Evans, SV, Polakowski, R, Letts, JA, Zheng, RB, Palcic, MM, Lowary, TL	J. Biol. Chem.	2008
8631849	Amino acid residue at codon 268 determines both activity and nucleotide-sugar donor substrate specificity of human histo-blood group A and B transferases. In vitro mutagenesis study Yamamoto, F, McNeill, PD	J. Biol. Chem.	1996
12198488	The structural basis for specificity in human ABO(H) blood group biosynthesis Marcus, SL, Seto, NO, Borisova, SN, Evans, SV, Patenaude, SI, Szpacenko, A, Palcic, MM	Nat. Struct. Biol.	2002
10092863	Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli Evans, SV, Bundle, DR, Palcic, MM, Compston, CA, Seto, NO, Narang, SA	Eur. J. Biochem.	1999
17259183	Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif Hosseini-Maaf, B, Borisova, SN, Persson, M, Olsson, ML, Evans, SV, Letts, JA, Palcic, MM	J. Biol. Chem.	2007