Reactome | PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6

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PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 Show undefined attributes

authored	[InstanceEdit:9033237] May, Bruce, 2017-12-19
category	binding
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033525] May, Bruce, 2017-12-22
dbId	9033516
displayName	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
edited	[InstanceEdit:9033237] May, Bruce, 2017-12-19
eventOf	[Pathway:R-HSA-9033241] Peroxisomal protein import - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Homo sapiens
input	[Complex:R-HSA-9033100] PEX1:PEX6:PEX26 [peroxisomal membrane] [Complex:R-HSA-9033497] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] [EntityWithAccessionedSequence:R-HSA-9033138] ZFAND6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033627] Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p [LiteratureReference:9033631] AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase [LiteratureReference:9033761] AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import [LiteratureReference:9036548] Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis [LiteratureReference:9036550] The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
orthologousEvent	[Reaction:R-GGA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Gallus gallus [Reaction:R-SSC-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Sus scrofa [Reaction:R-BTA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Bos taurus [Reaction:R-RNO-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Rattus norvegicus [Reaction:R-MMU-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Mus musculus
output	[Complex:R-HSA-9033532] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
precedingEvent	[Reaction:R-HSA-9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 - Homo sapiens
releaseDate	2018-03-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033516
summation	[Summation:9033920] PEX1:PEX6:PEX26 (known as the Receptor Export Module) extrac...
updateTrackers	[UpdateTracker:9779523] Update Tracker - [Reaction:9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779523] Update Tracker - [Reaction:9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - v65:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
(hasEvent)	[Pathway:R-HSA-9033241] Peroxisomal protein import