Reactome | PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6

Schema > Reaction > Entries

PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 Show undefined attributes

category	binding
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10210365
displayName	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
eventOf	[Pathway:R-RNO-9033241] Peroxisomal protein import - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Homo sapiens
input	[Complex:R-RNO-9033100] PEX1:PEX6:PEX26 [peroxisomal membrane] [Complex:R-RNO-9033497] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] [EntityWithAccessionedSequence:R-RNO-9033138] ZFAND6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
output	[Complex:R-RNO-9033532] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
precedingEvent	[Reaction:R-RNO-9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9033516
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9033241] Peroxisomal protein import
(precedingEvent)	[BlackBoxEvent:R-RNO-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
(inferredTo)	[Reaction:R-HSA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6

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