Reactome | PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol

Schema > BlackBoxEvent > Entries

PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol Show undefined attributes

authored	[InstanceEdit:9033237] May, Bruce, 2017-12-19
catalystActivity	[CatalystActivity:9033893] ATPase-coupled transmembrane transporter activity of PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
catalystActivityReference	[CatalystActivityReference:9643627] ATPase activity, coupled to movement of substances of PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
category	uncertain
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033525] May, Bruce, 2017-12-22
dbId	9033499
displayName	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
edited	[InstanceEdit:9033237] May, Bruce, 2017-12-19
eventOf	[Pathway:R-HSA-9033241] Peroxisomal protein import - Homo sapiens
followingEvent	[Reaction:R-HSA-9033509] USP9X binds Ub:PEX5L - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9033532] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033745] The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders [LiteratureReference:9033761] AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import [LiteratureReference:9033866] Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes [LiteratureReference:9033849] Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I [LiteratureReference:9033631] AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase [LiteratureReference:9033005] A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
orthologousEvent	[BlackBoxEvent:R-GGA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Gallus gallus [BlackBoxEvent:R-SSC-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Sus scrofa [BlackBoxEvent:R-BTA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Bos taurus [BlackBoxEvent:R-RNO-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Rattus norvegicus [BlackBoxEvent:R-MMU-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9033606] PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Complex:R-HSA-9033100] PEX1:PEX6:PEX26 [peroxisomal membrane] [EntityWithAccessionedSequence:R-HSA-9033107] PEX7 [cytosol] [Complex:R-HSA-9033504] Ub:PEX5L [cytosol] [EntityWithAccessionedSequence:R-HSA-9033138] ZFAND6 [cytosol]
precedingEvent	[Reaction:R-HSA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Homo sapiens
releaseDate	2018-03-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9033499
summation	[Summation:9033899] Ubiquitinated PEX5 isoform L (Ub:PEX5L) is released from the...
updateTrackers	[UpdateTracker:9779428] Update Tracker - [BlackBoxEvent:9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779428] Update Tracker - [BlackBoxEvent:9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-HSA-9033509] USP9X binds Ub:PEX5L