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Peroxisomal protein import
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authored
[InstanceEdit:9032610] May, Bruce, 2017-12-15
compartment
[Compartment:70101] cytosol
[Compartment:17951] peroxisomal matrix
[Compartment:17947] peroxisomal membrane
created
[InstanceEdit:9033234] May, Bruce, 2017-12-19
dbId
9033241
displayName
Peroxisomal protein import
doi
10.3180/R-HSA-9033241.1
edited
[InstanceEdit:9032610] May, Bruce, 2017-12-15
eventOf
[TopLevelPathway:R-HSA-9609507] Protein localization - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9033233] PEX5S,L binds cargo proteins containing PTS1 - Homo sapiens
[Reaction:R-HSA-9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) - Homo sapiens
[BlackBoxEvent:R-HSA-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Homo sapiens
[Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 - Homo sapiens
[Reaction:R-HSA-8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 - Homo sapiens
[Reaction:R-HSA-9033533] PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Homo sapiens
[BlackBoxEvent:R-HSA-9033505] PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 - Homo sapiens
[Reaction:R-HSA-9033526] USP9X binds Ub:PEX5S - Homo sapiens
[Reaction:R-HSA-9033478] USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin - Homo sapiens
[Reaction:R-HSA-9033232] PEX7 binds cargo proteins containing PTS2 - Homo sapiens
[Reaction:R-HSA-9033240] PEX5L binds PEX7:Cargo protein - Homo sapiens
[Reaction:R-HSA-9033238] PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) - Homo sapiens
[BlackBoxEvent:R-HSA-9033514] Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix - Homo sapiens
[Reaction:R-HSA-9033527] PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 - Homo sapiens
[Reaction:R-HSA-9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 - Homo sapiens
[Reaction:R-HSA-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Homo sapiens
[BlackBoxEvent:R-HSA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Homo sapiens
[Reaction:R-HSA-9033509] USP9X binds Ub:PEX5L - Homo sapiens
[Reaction:R-HSA-9033491] USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin - Homo sapiens
[Pathway:R-HSA-9033500] TYSND1 cleaves peroxisomal proteins - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9034445] Peroxisomes: a nexus for lipid metabolism and cellular signaling
[LiteratureReference:9034443] The first minutes in the life of a peroxisomal matrix protein
[LiteratureReference:9034442] Protein transport into peroxisomes: Knowns and unknowns
[LiteratureReference:9034417] Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives
[LiteratureReference:9034414] Peroxisomal protein import pores
[LiteratureReference:9034432] Regulation of peroxisomal matrix protein import by ubiquitination
[LiteratureReference:9034416] ATP-driven processes of peroxisomal matrix protein import
[LiteratureReference:9034415] Peroxisome protein import: a complex journey
[LiteratureReference:9034427] Structural biology of the import pathways of peroxisomal matrix proteins
[LiteratureReference:9034446] Peroxisome biogenesis and human peroxisome-deficiency disorders
[LiteratureReference:9034426] Peroxisome biogenesis in mammalian cells
[LiteratureReference:9034429] Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import
[LiteratureReference:9036568] Human disorders of peroxisome metabolism and biogenesis
[LiteratureReference:9036571] Peroxisome assembly: matrix and membrane protein biogenesis
[LiteratureReference:9036558] Assembly, maintenance and dynamics of peroxisomes
[LiteratureReference:9036572] A conserved tripeptide sorts proteins to peroxisomes
[LiteratureReference:9036556] A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase
[LiteratureReference:9036589] Import of stably folded proteins into peroxisomes
[LiteratureReference:9036590] The peroxisomal importomer constitutes a large and highly dynamic pore
[LiteratureReference:9033021] PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14
[LiteratureReference:9036588] Pex5p imports folded tetrameric catalase by interaction with Pex13p
[LiteratureReference:9033013] Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata
[LiteratureReference:9033036] An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes
[LiteratureReference:9033856] The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p
[LiteratureReference:9033043] Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import
[LiteratureReference:9036563] Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor
[LiteratureReference:9033031] Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
[LiteratureReference:9033629] The energetics of Pex5p-mediated peroxisomal protein import
[LiteratureReference:9036581] Peroxisomal matrix protein receptor ubiquitination and recycling
[LiteratureReference:9033608] Ubiquitination of mammalian Pex5p, the peroxisomal import receptor
[LiteratureReference:9033762] Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol
[LiteratureReference:9036587] Translocation of acyl-CoA oxidase into peroxisomes requires ATP hydrolysis but not a membrane potential
[LiteratureReference:9033005] A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway
[LiteratureReference:9033496] Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate
[LiteratureReference:9033919] The peroxisomal protein import machinery displays a preference for monomeric substrates
[LiteratureReference:9036910] Characterization of the mammalian peroxisomal import machinery: Pex2p, Pex5p, Pex12p, and Pex14p are subunits of the same protein assembly
[LiteratureReference:9033631] AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
[LiteratureReference:9033082] Revisiting the intraperoxisomal pathway of mammalian PEX7
[LiteratureReference:9038623] The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
[LiteratureReference:9033827] A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
Peroxisomal protein import
orthologousEvent
[Pathway:R-SCE-9033241] Peroxisomal protein import - Saccharomyces cerevisiae
[Pathway:R-SPO-9033241] Peroxisomal protein import - Schizosaccharomyces pombe
[Pathway:R-DDI-9033241] Peroxisomal protein import - Dictyostelium discoideum
[Pathway:R-CEL-9033241] Peroxisomal protein import - Caenorhabditis elegans
[Pathway:R-DME-9033241] Peroxisomal protein import - Drosophila melanogaster
[Pathway:R-GGA-9033241] Peroxisomal protein import - Gallus gallus
[Pathway:R-XTR-9033241] Peroxisomal protein import - Xenopus tropicalis
[Pathway:R-DRE-9033241] Peroxisomal protein import - Danio rerio
[Pathway:R-SSC-9033241] Peroxisomal protein import - Sus scrofa
[Pathway:R-BTA-9033241] Peroxisomal protein import - Bos taurus
[Pathway:R-CFA-9033241] Peroxisomal protein import - Canis familiaris
[Pathway:R-RNO-9033241] Peroxisomal protein import - Rattus norvegicus
[Pathway:R-MMU-9033241] Peroxisomal protein import - Mus musculus
releaseDate
2018-03-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9036917] Fransen, Marc, 2018-02-13
[InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13
[InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9033241
summation
[Summation:9034434] Peroxisomes are small cellular organelles that are bounded b...
Referrals
(hasEvent)
[TopLevelPathway:R-HSA-9609507] Protein localization
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