Reactome | PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol

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PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10087343] ATPase-coupled transmembrane transporter activity of PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
category	omitted
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10087345
displayName	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
eventOf	[Pathway:R-MMU-9033241] Peroxisomal protein import - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9033509] USP9X binds Ub:PEX5L - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9033532] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9033606] PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Complex:R-MMU-9033100] PEX1:PEX6:PEX26 [peroxisomal membrane] [EntityWithAccessionedSequence:R-MMU-9033107] Pex7 [cytosol] [Complex:R-MMU-9033504] Ub:PEX5L [cytosol] [EntityWithAccessionedSequence:R-MMU-9033138] ZFAND6 [cytosol]
precedingEvent	[Reaction:R-MMU-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9033499
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-MMU-9033509] USP9X binds Ub:PEX5L
(inferredTo)	[BlackBoxEvent:R-HSA-9033499] PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol

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