Reactome | PEX7 binds cargo proteins containing PTS2

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PEX7 binds cargo proteins containing PTS2 Show undefined attributes

authored	[InstanceEdit:9032610] May, Bruce, 2017-12-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9033234] May, Bruce, 2017-12-19
dbId	9033232
displayName	PEX7 binds cargo proteins containing PTS2
edited	[InstanceEdit:9032610] May, Bruce, 2017-12-15
eventOf	[Pathway:R-HSA-9033241] Peroxisomal protein import - Homo sapiens
followingEvent	[Reaction:R-HSA-9033240] PEX5L binds PEX7:Cargo protein - Homo sapiens
input	[DefinedSet:R-HSA-9033139] Cargo proteins containing PTS2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9033107] PEX7 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033025] Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7 [LiteratureReference:9033081] Structural requirements for interaction of peroxisomal targeting signal 2 and its receptor PEX7 [LiteratureReference:9033013] Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata [LiteratureReference:9033822] PEX7 gene structure, alternative transcripts, and evidence for a founder haplotype for the frequent RCDP allele, L292ter [LiteratureReference:9033867] Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor [LiteratureReference:9033751] Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor [LiteratureReference:9033851] Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins [LiteratureReference:9033860] Mutational spectrum in the PEX7 gene and functional analysis of mutant alleles in 78 patients with rhizomelic chondrodysplasia punctata type 1
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PEX7 binds cargo proteins containing PTS2
orthologousEvent	[Reaction:R-SCE-9033232] PEX7 binds cargo proteins containing PTS2 - Saccharomyces cerevisiae [Reaction:R-DDI-9033232] PEX7 binds cargo proteins containing PTS2 - Dictyostelium discoideum [Reaction:R-DME-9033232] PEX7 binds cargo proteins containing PTS2 - Drosophila melanogaster [Reaction:R-GGA-9033232] PEX7 binds cargo proteins containing PTS2 - Gallus gallus [Reaction:R-DRE-9033232] PEX7 binds cargo proteins containing PTS2 - Danio rerio [Reaction:R-SSC-9033232] PEX7 binds cargo proteins containing PTS2 - Sus scrofa [Reaction:R-BTA-9033232] PEX7 binds cargo proteins containing PTS2 - Bos taurus [Reaction:R-CFA-9033232] PEX7 binds cargo proteins containing PTS2 - Canis familiaris [Reaction:R-RNO-9033232] PEX7 binds cargo proteins containing PTS2 - Rattus norvegicus [Reaction:R-MMU-9033232] PEX7 binds cargo proteins containing PTS2 - Mus musculus
output	[Complex:R-HSA-9033142] PEX7:Cargo proteins [cytosol]
releaseDate	2018-03-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033232
summation	[Summation:9033853] Cytosolic PEX7 binds peroxisome targeting signal 2 (PTS2), a...
updateTrackers	[UpdateTracker:9779554] Update Tracker - [Reaction:9033232] PEX7 binds cargo proteins containing PTS2 - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779554] Update Tracker - [Reaction:9033232] PEX7 binds cargo proteins containing PTS2 - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-HSA-9033240] PEX5L binds PEX7:Cargo protein

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