Cytosolic PEX7 binds peroxisome targeting signal 2 (PTS2), a...

created [InstanceEdit:9033817] May, Bruce, 2017-12-28
dbId 9033853
displayName Cytosolic PEX7 binds peroxisome targeting signal 2 (PTS2), a...
modified [InstanceEdit:9038630] May, Bruce, 2018-03-12
schemaClass Summation
text Cytosolic PEX7 binds peroxisome targeting signal 2 (PTS2), a sequence of nine amino acid residues functionally identified in 3 human peroxisomal matrix proteins (Braverman et al. 1997, Motley et al. 1997, Purdue et al. 1997, Braverman et al. 2000, Ghys et al. 2002, Motley et al. 2002, Kunze et al. 2011, Kunze et al. 2015). According to molecular modeling, the PTS2 consensus sequence binds a groove in PEX7 (Kunze et al. 2011). Mutations in PEX7 cause rhizomelic chondrodysplasia punctata type 1 (Braverman et al. 1997, Motley et al. 1997, Purdue et al. 1997).
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