Reactome | SHC1 bound to activated NTRK2 recruits GRB2:SOS1

SHC1 bound to activated NTRK2 recruits GRB2:SOS1

Stable Identifier

R-HSA-9028328

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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SHC1 bound to activated NTRK2 recruits GRB2:SOS1

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NTRK2 (TRKB)-mediated activation of RAS signaling downstream of SHC1 recruitment is dependent on binding of the GRB2:SOS1 complex to tyrosine phosphorylated SHC1 (Chan et al. 2011).

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