SHC1 bound to activated NTRK2 recruits GRB2:SOS1

Stable Identifier
R-HSA-9028328
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SHC1 bound to activated NTRK2 recruits GRB2:SOS1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NTRK2 (TRKB)-mediated activation of RAS signaling downstream of SHC1 recruitment is dependent on binding of the GRB2:SOS1 complex to tyrosine phosphorylated SHC1 (Chan et al. 2011).

Participants
Input
Output
Participates
as an event of
Inferred From
Shc1 bound to activated Ntrk2 recruits Grb2:Sos1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-07)
Cite Us!