SHC1 bound to activated NTRK2 recruits GRB2:SOS1

Stable Identifier
R-HSA-9028328
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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SHC1 bound to activated NTRK2 recruits GRB2:SOS1
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NTRK2 (TRKB)-mediated activation of RAS signaling downstream of SHC1 recruitment is dependent on binding of the GRB2:SOS1 complex to tyrosine phosphorylated SHC1 (Chan et al. 2011).

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Shc1 bound to activated Ntrk2 recruits Grb2:Sos1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-07)