Activated NTRK2 signals through RAS

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Homo sapiens
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Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).

Literature References
PubMed ID Title Journal Year
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL

McCarty, JH, Feinstein, SC

J. Recept. Signal Transduct. Res. 1999
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Minichiello, L, Casagranda, F, Tatche, RS, Stucky, CL, Postigo, A, Lewin, GR, Davies, AM, Klein, R

Neuron 1998
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
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