Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).
Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L
Feinstein, SC, McCarty, JH
Yuen, EC, Mobley, WC
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