NTF4 activates NTRK2 (TRKB) signaling

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R-HSA-9026357
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Pathway
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Homo sapiens
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Signaling by the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) can be activated by binding to neurotrophin-4 (NTF4, also known as NT-4), which functions as a ligand for NTRK2 (Klein et al. 1992, Ip et al. 1993, Ohira et al. 2001). Binding to NTF4 triggers NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Minichiello et al. 1998). Phosphorylated tyrosine residues subsequently serve as docking sites for recruitment of effector proteins that trigger downstream signaling cascades.

Literature References
PubMed ID Title Journal Year
11536331 TrkB dimerization during development of the prefrontal cortex of the macaque

Ohira, K, Shimizu, K, Hayashi, M

J. Neurosci. Res. 2001
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Minichiello, L, Casagranda, F, Tatche, RS, Stucky, CL, Postigo, A, Lewin, GR, Davies, AM, Klein, R

Neuron 1998
1375038 The trkB tyrosine protein kinase is a receptor for neurotrophin-4

Klein, R, Lamballe, F, Bryant, S, Barbacid, M

Neuron 1992
7688038 Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF

Ip, NY, Li, Y, Yancopoulos, GD, Lindsay, RM

J. Neurosci. 1993
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