Reactome | ALOX15 oxidises 17(S)-Hp-DHA to PDX

ALOX15 oxidises 17(S)-Hp-DHA to PDX

Stable Identifier

R-HSA-9024872

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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15-lipoxygenase (ALOX15) can mediate a second lipoxygenation reaction where 17(S)-Hp-DHA is oxidised to the production of the protectin D1 (PD1) isomer PDX (Hong et al. 2003, Serhan et al. 2006, Chen et al. 2009). The chemical structure of PDX is 10(S),17(S)-dihydroxy-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid. It differs from PD1, having E,Z,E geometry (PDX) instead of E,E,Z (PD1) and S configuration at carbon 10 instead of R (Chen et al. 2009). PDX is not a major product of leukocytes and has low potency compared to PD1 as a regulator of polymorphonuclear leukocyte (PMN) infiltration (Serhan et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16424216	Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes Lu, Y, Serhan, CN, Colgan, SP, Petasis, NA, Hong, S, Baer, T, Yang, R, Gotlinger, K, Siegelman, J	J. Immunol.	2006
12590139	Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation Serhan, CN, Gronert, K, Devchand, PR, Hong, S, Moussignac, RL	J. Biol. Chem.	2003
19818771	Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation Guichardant, M, Fenet, B, Véricel, E, Tomczyk, N, Michaud, S, Lagarde, M, Chen, P	FEBS Lett.	2009