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Biosynthesis of protectins
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authored
[InstanceEdit:9018680] Jassal, Bijay, 2017-09-04
created
[InstanceEdit:9018680] Jassal, Bijay, 2017-09-04
crossReference
[DatabaseIdentifier:12325448] BioModels Database:BIOMD0000000106
dbId
9018681
displayName
Biosynthesis of protectins
edited
[InstanceEdit:9018680] Jassal, Bijay, 2017-09-04
eventOf
[Pathway:R-HSA-9018677] Biosynthesis of DHA-derived SPMs - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:81415] long-chain fatty acid biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Homo sapiens
[Reaction:R-HSA-9024890] LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 - Homo sapiens
[Reaction:R-HSA-9037761] CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 - Homo sapiens
[Reaction:R-HSA-9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA - Homo sapiens
[Reaction:R-HSA-9020257] LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 - Homo sapiens
[BlackBoxEvent:R-HSA-9031807] Protectins translocate from cytosol to extracellular region - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9024800] Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance
[LiteratureReference:9024820] Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date
[LiteratureReference:9018737] Lipid mediators in the resolution of inflammation
[LiteratureReference:9024875] Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Biosynthesis of protectins
orthologousEvent
[Pathway:R-SCE-9018681] Biosynthesis of protectins - Saccharomyces cerevisiae
[Pathway:R-SPO-9018681] Biosynthesis of protectins - Schizosaccharomyces pombe
[Pathway:R-DDI-9018681] Biosynthesis of protectins - Dictyostelium discoideum
[Pathway:R-CEL-9018681] Biosynthesis of protectins - Caenorhabditis elegans
[Pathway:R-DME-9018681] Biosynthesis of protectins - Drosophila melanogaster
[Pathway:R-GGA-9018681] Biosynthesis of protectins - Gallus gallus
[Pathway:R-XTR-9018681] Biosynthesis of protectins - Xenopus tropicalis
[Pathway:R-DRE-9018681] Biosynthesis of protectins - Danio rerio
[Pathway:R-SSC-9018681] Biosynthesis of protectins - Sus scrofa
[Pathway:R-BTA-9018681] Biosynthesis of protectins - Bos taurus
[Pathway:R-CFA-9018681] Biosynthesis of protectins - Canis familiaris
[Pathway:R-RNO-9018681] Biosynthesis of protectins - Rattus norvegicus
[Pathway:R-MMU-9018681] Biosynthesis of protectins - Mus musculus
releaseDate
2018-03-21
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9018681
summation
[Summation:9020279] Docosahexaenoic acid (DHA), a major ?-3 polyunsaturated fatt...
Referrals
(hasEvent)
[Pathway:R-HSA-9018677] Biosynthesis of DHA-derived SPMs
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