Reactome | GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA

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GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA Show undefined attributes

catalystActivity	[CatalystActivity:10086657] phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086699
displayName	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA
eventOf	[Pathway:R-MMU-9018676] Biosynthesis of D-series resolvins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9020282] ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA - Mus musculus [Reaction:R-MMU-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Mus musculus
inferredFrom	[Reaction:R-HSA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024012] 17(S)-Hp-DHA [cytosol] 2 × [SimpleEntity:R-ALL-29450] GSH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione => (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
output	[SimpleEntity:R-ALL-9024815] 17(S)-HDHA [cytosol] [SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-MMU-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9020273
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9018676] Biosynthesis of D-series resolvins
(precedingEvent)	[Reaction:R-MMU-9020282] ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA [Reaction:R-MMU-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA
(inferredTo)	[Reaction:R-HSA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA

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