Reactome | ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA

Schema > Reaction > Entries

ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA Show undefined attributes

authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9020578] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
dbId	9020264
displayName	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
eventOf	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins - Homo sapiens
followingEvent	[Reaction:R-HSA-9020277] ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA - Homo sapiens [Reaction:R-HSA-9020249] Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6 - Homo sapiens
input	[SimpleEntity:R-ALL-9024815] 17(S)-HDHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9022657] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA
orthologousEvent	[Reaction:R-DDI-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Dictyostelium discoideum [Reaction:R-GGA-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Gallus gallus [Reaction:R-XTR-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Xenopus tropicalis [Reaction:R-DRE-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Danio rerio [Reaction:R-SSC-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Sus scrofa [Reaction:R-BTA-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Bos taurus [Reaction:R-CFA-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Canis familiaris [Reaction:R-RNO-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Rattus norvegicus [Reaction:R-MMU-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Mus musculus
output	[SimpleEntity:R-ALL-9024797] 4(S)-Hp-17(S)-HDHA [cytosol]
precedingEvent	[Reaction:R-HSA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9020264
summation	[Summation:9024817] Lipoxygenase 5 (ALOX5) can oxidise 17(S)-hydroxydocosahexaen...

Referrals

(precedingEvent)	[Reaction:R-HSA-9020277] ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA [Reaction:R-HSA-9020249] Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6
(hasEvent)	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins