Reactome | RHOQ GEFs activate RHOQ

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RHOQ GEFs activate RHOQ Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9018841] guanyl-nucleotide exchange factor activity of RHOQ GEFs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9018744] Orlic-Milacic, Marija, 2017-09-05
dbId	9018747
deleted	[Deleted:9768327] Deletion of instance: 194913
displayName	RHOQ GEFs activate RHOQ
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
eventOf	[Pathway:R-HSA-9013406] RHOQ GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9018746] RHOQ binds effectors at the plasma membrane - Homo sapiens [Reaction:R-HSA-9018745] RHOQ GAPs stimulate RHOQ GTPase activity - Homo sapiens [BlackBoxEvent:R-HSA-9018836] RHOQ translocates to the Golgi-associated vesicle membranes - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-9018839] RHOQ:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:9693523] TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin [LiteratureReference:8980733] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) [LiteratureReference:8980798] Direct involvement of the small GTP-binding protein Rho in lbc oncogene function [LiteratureReference:196533] Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases [LiteratureReference:9644214] Asef is a Cdc42-specific guanine nucleotide exchange factor [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:9695613] Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability [LiteratureReference:9695612] Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHOQ GEFs activate RHOQ
orthologousEvent	[Reaction:R-SCE-9018747] RHOQ GEFs activate RHOQ - Saccharomyces cerevisiae [Reaction:R-SPO-9018747] RHOQ GEFs activate RHOQ - Schizosaccharomyces pombe [Reaction:R-CEL-9018747] RHOQ GEFs activate RHOQ - Caenorhabditis elegans [Reaction:R-DME-9018747] RHOQ GEFs activate RHOQ - Drosophila melanogaster [Reaction:R-GGA-9018747] RHOQ GEFs activate RHOQ - Gallus gallus [Reaction:R-XTR-9018747] RHOQ GEFs activate RHOQ - Xenopus tropicalis [Reaction:R-DRE-9018747] RHOQ GEFs activate RHOQ - Danio rerio [Reaction:R-SSC-9018747] RHOQ GEFs activate RHOQ - Sus scrofa [Reaction:R-BTA-9018747] RHOQ GEFs activate RHOQ - Bos taurus [Reaction:R-CFA-9018747] RHOQ GEFs activate RHOQ - Canis familiaris [Reaction:R-RNO-9018747] RHOQ GEFs activate RHOQ - Rattus norvegicus [Reaction:R-MMU-9018747] RHOQ GEFs activate RHOQ - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-2316453] RHOQ:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018747
summation	[Summation:9693520] The following guanine nucleotide exchange factors (GEFs) wer...
updateTrackers	[UpdateTracker:9775964] Update Tracker - [Reaction:9018747] RHOQ GEFs activate RHOQ - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775964] Update Tracker - [Reaction:9018747] RHOQ GEFs activate RHOQ - v78:[modifyText]
(replacementInstances)	[Deleted:9768327] Deletion of instance: 194913
(precedingEvent)	[Reaction:R-HSA-9018746] RHOQ binds effectors at the plasma membrane [Reaction:R-HSA-9018745] RHOQ GAPs stimulate RHOQ GTPase activity [BlackBoxEvent:R-HSA-9018836] RHOQ translocates to the Golgi-associated vesicle membranes
(hasEvent)	[Pathway:R-HSA-9013406] RHOQ GTPase cycle

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