RHOQ GEFs activate RHOQ

Stable Identifier
R-HSA-9018747
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOQ and catalyze GDP to GTP exchange on RHOQ, resulting in formation of the active RHOQ:GTP complex:
ITSN1 (Jaiswal et al. 2013)
OBSCN (Coisy-Quivy et al. 2009)
PREX1 (Jaiswal et al. 2013)

ARHGEF9 was implicated as a RHOQ GEF by some (Papadopoulos et al. 2015) but not all (Jaiswal et al. 2013; Mayer et al. 2013) studies and is annotated as a candidate RHOQ GEF.

The following GEFs do not act on RHOQ:
AKAP13 (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF2 (Ren et al. 1998)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF4 (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
DNMBP (Jaiswal et al. 2013)
MCF2 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)
TRIO (Jaiswal et al. 2013)
VAV2 (Jaiswal et al. 2013)

Literature References
PubMed ID Title Journal Year
25678704 Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability

Papadopoulos, T, Schemm, R, Grubm├╝ller, H, Brose, N

J. Biol. Chem. 2015
24297911 Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

Mayer, S, Kumar, R, Jaiswal, M, Soykan, T, Ahmadian, MR, Brose, N, Betz, H, Rhee, JS, Papadopoulos, T

Proc. Natl. Acad. Sci. U.S.A. 2013
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Wang, Z, Kumamoto, Y, Wang, P, Gan, X, Lehmann, D, Smrcka, AV, Cohn, L, Iwasaki, A, Li, L, Wu, D

J. Biol. Chem. 2009
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
9857026 Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

Ren, Y, Li, R, Zheng, Y, Busch, H

J Biol Chem 1998
7721814 Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

Zheng, Y, Olson, MF, Hall, A, Cerione, RA, Toksoz, D

J. Biol. Chem. 1995
17214551 Asef is a Cdc42-specific guanine nucleotide exchange factor

Gotthardt, K, Ahmadian, MR

Biol. Chem. 2007
21454492 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Jaiswal, M, Gremer, L, Dvorsky, R, Haeusler, LC, Cirstea, IC, Uhlenbrock, K, Ahmadian, MR

J. Biol. Chem. 2011
19258391 TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin

Coisy-Quivy, M, Touzet, O, Bourret, A, Hipskind, RA, Mercier, J, Fort, P, Philips, A

J. Cell. Sci. 2009
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Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOQ GEFs [cytosol]

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