Reactome | RHOQ GEFs activate RHOQ

RHOQ GEFs activate RHOQ

Stable Identifier

R-HSA-9018747

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOQ and catalyze GDP to GTP exchange on RHOQ, resulting in formation of the active RHOQ:GTP complex:
ITSN1 (Jaiswal et al. 2013)
OBSCN (Coisy-Quivy et al. 2009)
PREX1 (Jaiswal et al. 2013)

ARHGEF9 was implicated as a RHOQ GEF by some (Papadopoulos et al. 2015) but not all (Jaiswal et al. 2013; Mayer et al. 2013) studies and is annotated as a candidate RHOQ GEF.

The following GEFs do not act on RHOQ:
AKAP13 (also known as Lbc) (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF2 (also known as GEF-H1) (Ren et al. 1998)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF4 (also known as Asef) (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
DNMBP (Jaiswal et al. 2013)
MCF2 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)
TRIO (Jaiswal et al. 2013)
VAV2 (Jaiswal et al. 2013)

Literature References

PubMed ID	Title	Journal	Year
24297911	Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission Papadopoulos, T, Soykan, T, Ahmadian, MR, Brose, N, Jaiswal, M, Rhee, JS, Betz, H, Mayer, S, Kumar, R	Proc. Natl. Acad. Sci. U.S.A.	2013
25678704	Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability Papadopoulos, T, Grubmüller, H, Brose, N, Schemm, R	J. Biol. Chem.	2015
19713215	Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 Lehmann, D, Gan, X, Wang, P, Wang, Z, Li, L, Smrcka, AV, Iwasaki, A, Wu, D, Cohn, L, Kumamoto, Y	J. Biol. Chem.	2009
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Ahmadian, MR, Jaiswal, M, Dvorsky, R	J. Biol. Chem.	2013
9857026	Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases Busch, H, Zheng, Y, Li, R, Ren, Y	J Biol Chem	1998
7721814	Direct involvement of the small GTP-binding protein Rho in lbc oncogene function Olson, MF, Cerione, RA, Toksoz, D, Hall, A, Zheng, Y	J. Biol. Chem.	1995
17214551	Asef is a Cdc42-specific guanine nucleotide exchange factor Ahmadian, MR, Gotthardt, K	Biol. Chem.	2007
21454492	Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) Cirstea, IC, Ahmadian, MR, Uhlenbrock, K, Jaiswal, M, Dvorsky, R, Gremer, L, Haeusler, LC	J. Biol. Chem.	2011
19258391	TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin Fort, P, Philips, A, Bourret, A, Hipskind, RA, Mercier, J, Touzet, O, Coisy-Quivy, M	J. Cell. Sci.	2009