Reactome | RHOQ GTPase cycle

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RHOQ GTPase cycle Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
created	[InstanceEdit:9013410] Orlic-Milacic, Marija, 2017-07-24
dbId	9013406
displayName	RHOQ GTPase cycle
doi	10.3180/R-HSA-9013406.2
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
eventOf	[Pathway:R-HSA-9012999] RHO GTPase cycle - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9018747] RHOQ GEFs activate RHOQ - Homo sapiens [Reaction:R-HSA-9018745] RHOQ GAPs stimulate RHOQ GTPase activity - Homo sapiens [Reaction:R-HSA-9018746] RHOQ binds effectors at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9018836] RHOQ translocates to the Golgi-associated vesicle membranes - Homo sapiens [Reaction:R-HSA-5627072] RHOQ binds GOPC:CFTR - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:9691167] Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding [LiteratureReference:9690976] Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling [LiteratureReference:9695452] The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology [LiteratureReference:9695476] Rho GTPase isoforms in cell motility: Don't fret, we have FRET [LiteratureReference:9695481] Rho GTPases in insulin-stimulated glucose uptake [LiteratureReference:9695485] The role of small GTPases in neuronal morphogenesis and polarity [LiteratureReference:9695491] Insulin signaling in microdomains of the plasma membrane [LiteratureReference:9695489] Insulin signaling: GLUT4 vesicles exit via the exocyst [LiteratureReference:9733596] GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion [LiteratureReference:9693365] Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth [LiteratureReference:9692765] Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways [LiteratureReference:196997] Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth [LiteratureReference:9733609] The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons [LiteratureReference:9693379] Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHOQ GTPase cycle
orthologousEvent	[Pathway:R-SCE-9013406] RHOQ GTPase cycle - Saccharomyces cerevisiae [Pathway:R-SPO-9013406] RHOQ GTPase cycle - Schizosaccharomyces pombe [Pathway:R-CEL-9013406] RHOQ GTPase cycle - Caenorhabditis elegans [Pathway:R-DME-9013406] RHOQ GTPase cycle - Drosophila melanogaster [Pathway:R-GGA-9013406] RHOQ GTPase cycle - Gallus gallus [Pathway:R-XTR-9013406] RHOQ GTPase cycle - Xenopus tropicalis [Pathway:R-DRE-9013406] RHOQ GTPase cycle - Danio rerio [Pathway:R-SSC-9013406] RHOQ GTPase cycle - Sus scrofa [Pathway:R-BTA-9013406] RHOQ GTPase cycle - Bos taurus [Pathway:R-CFA-9013406] RHOQ GTPase cycle - Canis familiaris [Pathway:R-RNO-9013406] RHOQ GTPase cycle - Rattus norvegicus [Pathway:R-MMU-9013406] RHOQ GTPase cycle - Mus musculus
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
revised	[InstanceEdit:9733840] Orlic-Milacic, Marija, 2021-06-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013406
summation	[Summation:9693566] This pathway catalogues RHOQ (also known as TC10) guanine nu...
updateTrackers	[UpdateTracker:9775657] Update Tracker - [Pathway:9013406] RHOQ GTPase cycle - v78:[addLiteratureReference, modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775657] Update Tracker - [Pathway:9013406] RHOQ GTPase cycle - v78:[addLiteratureReference, modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9012999] RHO GTPase cycle

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