Reactome | PXLP-K56-SRR dimer isomerises L-Ser to D-Ser

Schema > Reaction > Entries

PXLP-K56-SRR dimer isomerises L-Ser to D-Ser Show undefined attributes

authored	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
catalystActivity	[CatalystActivity:9014761] serine racemase activity of PXLP-K56-SRR dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9929613] serine racemase activity of PXLP-K56-SRR dimer [cytosol] Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
crossReference	[DatabaseIdentifier:12667714] RHEA:10981 [DatabaseIdentifier:9929624] RHEA:10981
dbId	9014766
displayName	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser
edited	[InstanceEdit:9014757] Jassal, Bijay, 2017-08-03
eventOf	[Pathway:R-HSA-977347] Serine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9014741] PXLP-K56-SRR dimer deaminates D-Ser - Homo sapiens [Reaction:R-HSA-9034539] PXLP-K56-SRR dimer deaminates L-Ser - Homo sapiens
input	[SimpleEntity:R-ALL-200736] L-Ser [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9014756] Serine racemase: a key player in apoptosis and necrosis [LiteratureReference:9014748] Human serine racemase: moleular cloning, genomic organization and functional analysis [LiteratureReference:9014781] Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine [LiteratureReference:9014735] Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity [LiteratureReference:9014770] The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding [LiteratureReference:9017152] Characterization and localization of a human serine racemase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-K56-SRR dimer isomerises L-Ser to D-Ser L-serine => D-serine
orthologousEvent	[Reaction:R-SCE-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Saccharomyces cerevisiae [Reaction:R-SPO-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Schizosaccharomyces pombe [Reaction:R-DDI-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Dictyostelium discoideum [Reaction:R-CEL-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Caenorhabditis elegans [Reaction:R-GGA-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Gallus gallus [Reaction:R-XTR-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Xenopus tropicalis [Reaction:R-SSC-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Sus scrofa [Reaction:R-BTA-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Bos taurus [Reaction:R-CFA-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Canis familiaris [Reaction:R-RNO-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Rattus norvegicus [Reaction:R-MMU-9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - Mus musculus
output	[SimpleEntity:R-ALL-376186] D-Ser [cytosol]
precedingEvent	[Reaction:R-HSA-977324] PSPH:Mg2+ dimer dephosphorylates O-P-Ser - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-9014745] Positive regulation by 'Mg2+ [cytosol]' [PositiveRegulation:R-HSA-9014767] Positive regulation by 'ATP [cytosol]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9034652] Wolosker, Herman, 2018-01-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014766
summation	[Summation:9014754] N-methyl D-aspartate (NMDA) receptors play a key role in exc...
updateTrackers	[UpdateTracker:9939629] Update Tracker - [Reaction:9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - v92:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9939629] Update Tracker - [Reaction:9014766] PXLP-K56-SRR dimer isomerises L-Ser to D-Ser - v92:[modifyText, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-9014741] PXLP-K56-SRR dimer deaminates D-Ser [Reaction:R-HSA-9034539] PXLP-K56-SRR dimer deaminates L-Ser
(hasEvent)	[Pathway:R-HSA-977347] Serine metabolism

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