Reactome | CDC42 GDIs block activation of CDC42

Schema > Reaction > Entries

CDC42 GDIs block activation of CDC42 Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013160] Orlic-Milacic, Marija, 2017-07-24
dbId	9013158
deleted	[Deleted:9768324] Deletion of instance: 194854
displayName	CDC42 GDIs block activation of CDC42
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
eventOf	[Pathway:R-HSA-9013148] CDC42 GTPase cycle - Homo sapiens
input	[DefinedSet:R-HSA-9013243] CDC42 GDIs [cytosol] [Complex:R-HSA-9013230] CDC42:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9681554] ARHGDIA: a novel gene implicated in nephrotic syndrome [LiteratureReference:9690973] Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I [LiteratureReference:196633] RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas [LiteratureReference:9692768] Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells [LiteratureReference:9692765] Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CDC42 GDIs block activation of CDC42
orthologousEvent	[Reaction:R-SCE-9013158] CDC42 GDIs block activation of CDC42 - Saccharomyces cerevisiae [Reaction:R-SPO-9013158] CDC42 GDIs block activation of CDC42 - Schizosaccharomyces pombe [Reaction:R-CEL-9013158] CDC42 GDIs block activation of CDC42 - Caenorhabditis elegans [Reaction:R-DME-9013158] CDC42 GDIs block activation of CDC42 - Drosophila melanogaster [Reaction:R-GGA-9013158] CDC42 GDIs block activation of CDC42 - Gallus gallus [Reaction:R-XTR-9013158] CDC42 GDIs block activation of CDC42 - Xenopus tropicalis [Reaction:R-DRE-9013158] CDC42 GDIs block activation of CDC42 - Danio rerio [Reaction:R-SSC-9013158] CDC42 GDIs block activation of CDC42 - Sus scrofa [Reaction:R-BTA-9013158] CDC42 GDIs block activation of CDC42 - Bos taurus [Reaction:R-CFA-9013158] CDC42 GDIs block activation of CDC42 - Canis familiaris [Reaction:R-RNO-9013158] CDC42 GDIs block activation of CDC42 - Rattus norvegicus [Reaction:R-MMU-9013158] CDC42 GDIs block activation of CDC42 - Mus musculus
output	[Complex:R-HSA-9013239] CDC42:GDP:CDC42 GDIs [cytosol]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013158
summation	[Summation:9692638] The following GDP dissociation inhibitors (GDIs) bind to CDC...

Referrals

(replacementInstances)	[Deleted:9768324] Deletion of instance: 194854
(hasEvent)	[Pathway:R-HSA-9013148] CDC42 GTPase cycle

Cite Us!