CDC42 GDIs block activation of CDC42

Stable Identifier
R-HSA-9013158
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The following GDP dissociation inhibitors (GDIs) bind to CDC42 and inhibit its activation:
ARHGDIA (Gupta et al. 2013; Murphy et al. 2001)
ARHGDIG (Adra et al. 1997)
ARHGDIB (Adra et al. 1993)
CAV1 (Nevins and Thurmond 2006)

Literature References
PubMed ID Title Journal Year
7512369 Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I

Adra, CN, Ko, J, Leonard, D, Wirth, LJ, Cerione, RA, Lim, B

Genes Chromosomes Cancer 1993
11306516 Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways

Murphy, GA, Jillian, SA, Michaelson, D, Philips, MR, D'Eustachio, P, Rush, MG

Cell Growth Differ. 2001
9113980 RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

Adra, CN, Manor, D, Ko, JL, Zhu, S, Horiuchi, T, Van Aelst, L, Cerione, RA, Lim, B

Proc Natl Acad Sci U S A 1997
16714282 Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells

Nevins, AK, Thurmond, DC

J. Biol. Chem. 2006
23434736 ARHGDIA: a novel gene implicated in nephrotic syndrome

Gupta, IR, Baldwin, C, Auguste, D, Ha, KC, El Andalousi, J, Fahiminiya, S, Bitzan, M, Bernard, C, Akbari, MR, Narod, SA, Rosenblatt, DS, Majewski, J, Takano, T

J. Med. Genet. 2013
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!