Reactome | CDC42 GTPase cycle

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CDC42 GTPase cycle Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
created	[InstanceEdit:9013146] Orlic-Milacic, Marija, 2017-07-24
dbId	9013148
displayName	CDC42 GTPase cycle
doi	10.3180/R-HSA-9013148.2
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25 [InstanceEdit:9733842] Orlic-Milacic, Marija, 2021-06-10
eventOf	[Pathway:R-HSA-9012999] RHO GTPase cycle - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9013159] CDC42 GEFs activate CDC42 - Homo sapiens [Reaction:R-HSA-9013161] CDC42 GAPs stimulate CDC42 GTPase activity - Homo sapiens [Reaction:R-HSA-9013158] CDC42 GDIs block activation of CDC42 - Homo sapiens [Reaction:R-HSA-9013157] CDC42 binds effectors at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9692800] CDC42 translocates to the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9692809] CDC42 binds effectors at the ER membrane - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:9695282] Targeting Rac and Cdc42 GEFs in Metastatic Cancer [LiteratureReference:9695291] Regulation of Cdc42 and its effectors in epithelial morphogenesis [LiteratureReference:9695297] Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs [LiteratureReference:9695309] Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases [LiteratureReference:9695313] Targeting Rac and Cdc42 GTPases in Cancer [LiteratureReference:9695318] Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates [LiteratureReference:9695321] Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility [LiteratureReference:9695328] Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras- Related Cancers [LiteratureReference:9695333] Emerging role of Cdc42-specific guanine nucleotide exchange factors as regulators of membrane trafficking in health and disease [LiteratureReference:9733557] Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor ?PIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CDC42 GTPase cycle
orthologousEvent	[Pathway:R-SCE-9013148] CDC42 GTPase cycle - Saccharomyces cerevisiae [Pathway:R-SPO-9013148] CDC42 GTPase cycle - Schizosaccharomyces pombe [Pathway:R-CEL-9013148] CDC42 GTPase cycle - Caenorhabditis elegans [Pathway:R-DME-9013148] CDC42 GTPase cycle - Drosophila melanogaster [Pathway:R-GGA-9013148] CDC42 GTPase cycle - Gallus gallus [Pathway:R-XTR-9013148] CDC42 GTPase cycle - Xenopus tropicalis [Pathway:R-DRE-9013148] CDC42 GTPase cycle - Danio rerio [Pathway:R-SSC-9013148] CDC42 GTPase cycle - Sus scrofa [Pathway:R-BTA-9013148] CDC42 GTPase cycle - Bos taurus [Pathway:R-CFA-9013148] CDC42 GTPase cycle - Canis familiaris [Pathway:R-RNO-9013148] CDC42 GTPase cycle - Rattus norvegicus [Pathway:R-MMU-9013148] CDC42 GTPase cycle - Mus musculus
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05 [InstanceEdit:9733837] Das, Maitreyi, 2021-05-17
revised	[InstanceEdit:9733840] Orlic-Milacic, Marija, 2021-06-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013148
summation	[Summation:9695277] This pathway catalogues CDC42 guanine nucleotide exchange fa...
updateTrackers	[UpdateTracker:9775528] Update Tracker - [Pathway:9013148] CDC42 GTPase cycle - v78:[addLiteratureReference, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775528] Update Tracker - [Pathway:9013148] CDC42 GTPase cycle - v78:[addLiteratureReference, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9012999] RHO GTPase cycle

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