Reactome | p-TEFb phosphorylates serine 2 in RNA polymerase II CTD

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p-TEFb phosphorylates serine 2 in RNA polymerase II CTD Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
catalystActivity	[CatalystActivity:9012314] protein serine/threonine kinase activity of MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9012318] Rothfels, Karen, 2017-07-12
dbId	9012319
displayName	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9011971] Estrogen-responsive MYB gene expression - Homo sapiens
input	52 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-9012311] MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012455] Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells [LiteratureReference:9012450] Estrogen receptor-? recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
orthologousEvent	[Reaction:R-PFA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Plasmodium falciparum [Reaction:R-SCE-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Saccharomyces cerevisiae [Reaction:R-SPO-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Schizosaccharomyces pombe [Reaction:R-DDI-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Dictyostelium discoideum [Reaction:R-CEL-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Caenorhabditis elegans [Reaction:R-DME-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Drosophila melanogaster [Reaction:R-GGA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Gallus gallus [Reaction:R-XTR-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Xenopus tropicalis [Reaction:R-SSC-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Sus scrofa [Reaction:R-BTA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Bos taurus [Reaction:R-CFA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Canis familiaris [Reaction:R-RNO-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Rattus norvegicus [Reaction:R-MMU-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Mus musculus
output	52 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-9012290] MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9012315] ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9012319
summation	[Summation:9012472] Transcriptional pausing at the SL-dT site in the MYB gene is...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[BlackBoxEvent:R-HSA-9011971] Estrogen-responsive MYB gene expression

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