Reactome | Estrogen-responsive MYB gene expression

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Estrogen-responsive MYB gene expression Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9011970] Rothfels, Karen, 2017-07-06
dbId	9011971
displayName	Estrogen-responsive MYB gene expression
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8956588] MYB gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9012471] Strong association between c-myb and oestrogen-receptor expression in human breast cancer [LiteratureReference:9012479] MYB oncogene amplification in hereditary BRCA1 breast cancer [LiteratureReference:9012461] Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype [LiteratureReference:9010349] Genome-wide analysis of estrogen receptor binding sites [LiteratureReference:9012439] Differential expression of c-myb mRNA in murine B lymphomas by a block to transcription elongation [LiteratureReference:9012435] A transcriptional arrest mechanism involved in controlling constitutive levels of mouse c-myb mRNA [LiteratureReference:9012455] Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells [LiteratureReference:9012450] Estrogen receptor-? recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene [LiteratureReference:9012446] Estrogen and MYB in breast cancer: potential for new therapies [LiteratureReference:9012438] Cellular control of gene expression by T-type cyclin/CDK9 complexes [LiteratureReference:9011656] Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development [LiteratureReference:9011806] KDM4B is a master regulator of the estrogen receptor signalling cascade [LiteratureReference:9011819] The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth [LiteratureReference:9011833] The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Estrogen-responsive MYB gene expression
output	[EntityWithAccessionedSequence:R-HSA-992697] MYB [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9011972] Positive gene expression regulation by 'MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm]'
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9011971
summation	[Summation:9012484] MYB is frequently expressed in breast cancer and its express...

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[Pathway:R-HSA-9018519] Estrogen-dependent gene expression

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