FOXA1 and GATA3 bind to CCND1 promoter

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Reaction [transition]
Homo sapiens
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Estrogen induces cellular proliferation by upregulating expression of critical cell cycle regulators that govern progression through G1, such as Myc and Cyclin D1 (reviewed in Butt et al, 2005). In the absence of estrogen, Cyclin D1 expression is inhibited, at least in part, by the binding of a transcriptional repressor complex YY1:HDAC1 to the promoter (Cicatiello et al, 2004). Estrogen-stimulated induction of target gene expression appears in many cases to be primed by the binding of 'pioneer' transcription factors, such as FOXA and GATA family proteins (Carroll et al, 2005; Laganière et al, 2005; Eeckhoute et al, 2006; Hurtado et al, 2011; Kong et al, 2011; Theodorou et al, 2013; Swinstead et al, 2016; reviewed in Zaret and Carroll, 2011; Augello et al, 2011; Fiorito et al, 2013; Wilson and Giguere, 2008). FOXA factors have a winged helix structure that is thought to bind to closed chromatin structures in a manner analogous to linker histones, displacing linker histones and rendering the DNA more accessible to other transcription factors (reviewed in Zaret and Carroll, 2011). FOXA binding sites tend to be enriched at enhancer elements, characterized by H3K4 mono- and dimethylation, and expression of the histone demethylase KDM1A abrogates FOXA recruitment (Lupien et al, 2008). An enhancer element has been defined downstream of the CCND1 gene that mediates the binding of both the pioneer factor FOXA1 and estrogen-responsive ESR1 (Eeckhoute et al, 2006).

Literature References
PubMed ID Title Journal Year
21878914 Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state

Kong, SL, Li, G, Liu, ET, Loh, SL, Sung, WK

Mol. Syst. Biol. 2011
15282324 Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter

Caristi, S, Perillo, B, Borgo, R, Addeo, R, Altucci, L, Scafoglio, C, Caporali, S, Cancemi, M, Teti, D, Sasso, A, Cicatiello, L, Weisz, A, Petrizzi, VB, Bresciani, F

Mol. Cell. Biol. 2004
21151129 FOXA1 is a key determinant of estrogen receptor function and endocrine response

Ross-Innes, CS, Hurtado, A, Carroll, JS, Holmes, KA, Schmidt, D

Nat. Genet. 2011
18358809 FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

Brown, M, Li, W, Zhang, Y, Wang, Q, Liu, XS, Eeckhoute, J, Carroll, JS, Meyer, CA, Lupien, M

Cell 2008
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
16087863 From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

Bataille, AR, Giguère, V, Robert, F, Lefebvre, C, Laganière, J, Deblois, G

Proc. Natl. Acad. Sci. U.S.A. 2005
21934649 FOXA1: master of steroid receptor function in cancer

Augello, MA, Hickey, TE, Knudsen, KE

EMBO J. 2011
23192763 Cooperating transcription factors mediate the function of estrogen receptor

Hurtado, A, Fiorito, E, Katika, MR

Chromosoma 2013
27062924 Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

Mazza, D, Swinstead, EE, Ball, D, Paakinaho, V, Miranda, TB, Grimm, JB, Karpova, TS, Hager, GL, Baek, S, Goldstein, I, Morisaki, T, Presman, DM, Grøntved, L, Lavis, LD, Hawkins, M

Cell 2016
18533032 Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway

Giguère, V, Wilson, BJ

Mol. Cancer 2008
16980581 A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer

Brown, M, Geistlinger, TR, Torres-Arzayus, MI, Eeckhoute, J, Carroll, JS

Genes Dev. 2006
16113099 Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E

McNeil, CM, Musgrove, EA, Butt, AJ, Sutherland, RL

Endocr. Relat. Cancer 2005
16009131 Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

Szary, AJ, Shao, W, Li, W, Geistlinger, TR, Liu, XS, Hestermann, EV, Meyer, CA, Brodsky, AS, Silver, PA, Fox, EA, Brown, M, Eeckhoute, J, Carroll, JS

Cell 2005
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Stark, R, Menon, S, Carroll, JS, Theodorou, V

Genome Res. 2013
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