Reactome | RUNX2 binds HDAC6

RUNX2 binds HDAC6

Stable Identifier

R-HSA-9008389

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - RUNX2 regulates bone development (Homo sapiens)
        
        RUNX2 regulates osteoblast differentiation (Homo sapiens)
        
        RUNX2 binds HDAC6 (Homo sapiens)

General

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Based on studies in rat osteoblast, RUNX2 forms a complex with the histone deacetylase HDAC6 (Westendorf et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12391164	Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter Westendorf, JJ, Zaidi, SK, Cascino, JE, Kahler, R, van Wijnen, AJ, Lian, JB, Yoshida, M, Stein, GS, Li, X	Mol. Cell. Biol.	2002