RUNX2-P1 binds RUNX2 gene promoter

Stable Identifier
R-HSA-9008345
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2-P1 binds RUNX2 gene promoter
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Based on studies in mice, RUNX2-P1 (RUNX2 variant expressed from the distal promoter) binds to RUNX2 response elements in the distal promoter of the RUNX2 gene, which are conserved in rat and human RUNX2 promoters (Drissi et al. 2000). It is assumed that RUNX2 is associated with at least CBFB and the RUNX2 promoter, although this has not been examined.
Literature References
PubMed ID Title Journal Year
10911365 Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene

Drissi, H, Luc, Q, Shakoori, R, Chuva De Sousa Lopes, S, Choi, JY, Terry, A, Hu, M, Jones, S, Neil, JC, Lian, JB, Stein, JL, Van Wijnen, AJ, Stein, GS

J. Cell. Physiol. 2000
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Runx2-P1 binds to Runx2 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-08)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-08)
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